It is important to note that the molecule isolated in Hoodia Gordonii does not necessarily affect the appetite when eating high carbohydrate or sugar diets or when hunger is caused by physical exercise. While P.57 can signal to the brain that the body is full, the sugar drops and physical requirement for nourishment can counteract these effects.
As with any weight loss program it is necessary to adapt diet and lifestyle to experience the most profound changes. Suppressing the appetite should not be a replacement for good nutrition and healthy living.